Hitting and neutralising intracellular protein interactions

Hitting and neutralising intracellular protein interactions with a precision never before achieved. This is the objective of PISA (Post-translational Intracellular Antibodies Silencing), a technology developed by a team of students and researchers led by Professor Antonino Cattaneo, Director of the Bio@SNS Laboratory of the Scuola Normale Superiore. The technique has been described in an article published in Nature Methods, and will allow for the first time to interfere selectively and specifically with chemically modified intracellular proteins, at the last stage of their biosynthesis.

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The study has seen the collaboration of the graduate students Michele Chirichella (first author of the work) and Marco Fantini, the research fellows Martina Goracci, Simonetta Lisi and Mariantonietta Calvello and the researcher Cristina Di Primio, together with researchers at EBRI, Euroepan Brain Research Institute, Rita-Levi Montalcini