Dr. Dario Riccardo Valenzano

DATE AND TIME: 3 May 2017, 11.00
LOCATION: 
Aula Dini
Pallazzo del Castelletto
Scuola Normale Superiore
Piazza del Castelletto, 5
Pisa
ATTENDEES: Open to the public 

SPEAKER: Dario Riccardo Valenzano, Max Planck Institute for the Biology of Agieng, Cologne, Germany

TITLE: “The short-lived turquoise killifish sheds light on the basis of vertebrate aging”

Abstract: Gut bacteria occupy the interface between the organism and the external environment, contributing to homeostasis and disease. Yet, the causal role of the gut microbiota during host aging is largely unexplored. Here, using the African turquoise killifish (Nothobranchius furzeri), a naturally short-lived vertebrate, we show that the gut microbiota plays a key role in modulating vertebrate life span. Recolonizing the gut of middle-age individuals with bacteria from young donors resulted in life span extension and delayed behavioral decline. This intervention prevented the decrease in microbial diversity associated with host aging and maintained a young-like gut bacterial community, characterized by overrepresentation of the key genera Exiguobacterium, Planococcus, Propionigenium and Psychrobacter. Our findings demonstrate that the natural microbial gut community of young individuals can causally induce long-lasting beneficial systemic effects that lead to life span extension in a vertebrate model.