SPEAKER: Peter Scheiffele (University of Basel)
TITLE: “RNA-Splicing Codes for Synapse Specification and Dynamic Gene Regulation in Neuronal Circuits“
Abstract: The assembly of functional neuronal circuits during development relies on an intricate interplay of cellular interactions, molecular recognition signals, and neuronal activity-dependent processes. Over the past 20 years, families of neuronal cell surface receptors have been identified that may exhibit remarkable molecular diversity. This diversity has been hypothesized to underlie selective trans-cellular interactions and cell-type specific properties, providing a molecular code for aspects of synaptic specificity. We will discuss recent studies on the role of alternative splicing programs in shaping the molecular diversity in neurons and regulating aspects of synaptic specificity.