SPEAKER: VANESSA HALL
University of Copenhagen
TITLE: “Exploring the cytoarchitecture of the developing entorhinal cortex“
The entorhinal cortex (EC) is located in the ventral telencephalon of the brain and is important for processing spatial and object information. The medial EC (MEC) houses many unique cells, including the grid cells, the conjunctive grid cells, the border cells, the speed cells and the head-direction cells. These cells have been characterized based on their firing patterns however, there are very few or no molecular markers which can identify or distinguish between these cell types. To address this, we performed a detailed anatomical and molecular characterization of the developing pig EC using histology, postmortem structural MRI, diffusion tensor imaging and single-cell sequencing. We determined that the pig developing EC has a unique cortical lamination pattern. We have also identified the transcriptional profiles of radial glia and intermediate progenitors that give rise to the EC-specific neurons as well as several different types of excitatory and inhibitory neurons that exist. Overall, our work demonstrates the temporal development of the EC in a large mammalian species and specific molecular signatures of a diverse range of progenitors and neurons present.