Investigating the mechanisms of degeneration of human entorhinal neurons and their relationship with altered patterns of neuronal activity, using in vitro corticalized hiPSCs. The ability to model in vitro the embryonic development, the synaptic maturation and the activity of human entorhinal neurons will allow the team to investigate the initial steps of Alzheimer disease neurodegeneration.

People: 

Fabrizio Tonelli PostDoc

Eleonora Crocco PhD student

Greta Ghiloni PhD student

Filippo Cancellotti, PhD student

Collaborations:

• CNR-IN – Claudia Alia, in vivo grafting of in vitro-generated mouse and human neurons.
• CNR-IBF – Angelo di Garbo, analysis of cortical neural network activity with MEA.
• CNR-ISTI – Giuseppe Amato, assays of synaptic potentiation in cortical neuronal networks by MEA.
• CNR-IFC – Milena Rizzo, analysis of miRNA expression during corticogenesis
• University of Nice Sophia Antipolis | UNS I Nice (France) – Michèle Studer, cortical organoids.